You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Details for Patent: 8,663,158


✉ Email this page to a colleague

« Back to Dashboard


Title:Needleless injector drug capsule and a method for filling thereof
Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
Inventor(s): Henry; William (Cambridge, GB), Lewis; Andrew (Cambridge, GB)
Assignee: Zogenix, Inc. (Emeryville, CA)
Filing Date:Apr 18, 2013
Application Number:13/865,523
Claims:1. A needle free injector drug capsule, comprising: a container comprised of borosilicate glass strengthened with ion exchange; and a liquid formulation in the container, wherein the liquid formulation is comprised of a drug, and the liquid formulation has been purged by an inert gas having a solubility of 0.5 cm.sup.3 to 25 cm.sup.3 in 100 cm.sup.3 of the liquid formulation.

2. The needle free injector drug capsule of claim 1, wherein the inert gas solubility in the formulation over a range of temperatures from 0.degree. C. to 30.degree. C. is such that the inert gas does not come out of solution during temperature cycling.

3. A needle free injector drug capsule as claimed in claim 2, wherein the inert gas is selected from the group consisting of helium, argon, neon, krypton, xenon, nitrogen, a chlorofluorocarbon, a hydrofluorocarbon, and a mixture thereof.

4. A needle free injector drug capsule as claimed in claim 3, wherein the inert gas does not include helium.

5. The needle free injector drug capsule of claim 1, wherein the inert gas solubility in the formulation is such that gas does not come out of solution during storage over a range of temperatures corresponding to a temperature range expected during storage.

6. A needle free injector capsule as claimed in claim 5, wherein the range of temperatures is 0.degree. C. to 30.degree. C.

7. The needle free injector drug capsule as claimed in claim 1, wherein the inert gas is helium.

8. A needle free injector drug capsule, comprising: a container for use with a needle free injector; and a liquid formulation in the container, wherein the liquid formulation is comprised of a drug, and the liquid formulation has been purged by an inert gas having a solubility of 0.5 cm.sup.3 to 25 cm.sup.3 in 100 cm.sup.3 of the liquid formulation; wherein the inert gas solubility in the formulation is such that gas does not come out of solution during storage over a range of temperatures of 0.degree. C. to 30.degree. C.

9. A needle free injector drug capsule as claimed in claim 8, wherein the inert gas is selected from the group consisting of helium, argon, neon, krypton, xenon, nitrogen, a chlorofluorocarbon, a hydrofluorocarbon, and a mixture thereof.

10. A needle free injector drug capsule as claimed in claim 8, wherein the capsule is comprised of a polymer.

11. A needle free injector drug capsule as claimed in claim 10, wherein the polymer is a polycarbonate.

12. A needle free injector drug capsule as claimed in claim 8, wherein the capsule is comprised of glass.

13. A needle free injector drug capsule as claimed in claim 12, wherein the glass is strengthened via ion exchange.

14. A needle free injector drug capsule as claimed in claim 12, wherein the glass is borosilicate glass.

15. A needle free injector drug capsule as claimed in claim 8, wherein the inert gas is selected from the group consisting of helium, argon, neon, krypton, xenon, nitrogen, a chlorofluorocarbon, a hydrofluorocarbon, and a mixture thereof; and wherein the container is comprised of borosilicate glass strengthened via ion exchange.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.