Details for Patent: 7,696,220

Title:	Methods for the treatment or inhibition of ileus
Abstract:	Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered.
Inventor(s):	Farrar; John J. (Chester Springs, PA), Schied; Peter J. (Southampton, PA), Schmidt; William K. (Newark, DE), Carpenter; Randall L. (Waban, MA)
Assignee:	Adolor Corporation (Exton, PA)
Filing Date:	Jun 13, 2002
Application Number:	10/171,299
Claims:	1. A method of treating or inhibiting ileus comprising administering to a patient an effective amount of a peripheral mu opioid antagonist compound, wherein said peripheral mu opioid antagonist compound is the quaternary morphinan compound N-methylnaltrexone. 2. A method according to claim 1 wherein the ileus is selected from the group consisting of postsurgical ileus and postpartum ileus. 3. A method according to claim 2 wherein the ileus is post-surgical ileus. 4. A method according to claim 3 wherein said postsurgical ileus is postsurgical paralytic ileus. 5. A method according to claim 1 wherein the ileus is ileus of the colon. 6. A method according to claim 1 wherein the ileus occurs in the absence of exogenous opioid agonists. 7. A method according to claim 1 further comprising administering an opiate or an opioid to said patient. 8. A method according to claim 7 wherein said opiate or opioid comprises an opioid analgesic. 9. A method according to claim 8 wherein said opioid analgesic comprises a mu opioid agonist. 10. A method according to claim 1 further comprising administering to said patient a compound which slows gut motility.