Details for Patent: 6,218,373

Title:	Formulations containing hyaluronic acid
Abstract:	A method of treating a disease of condition administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage comprising a therapeutically effective amount of a drug to treat said disease or condition and a form of hyaluronic acid characterized in that the composition is immediately available to transport the drug percutaneously into the epidermis of the skin or exposed tissue to the site of trauma or pathology of the disease or condition to be treated.
Inventor(s):	Falk; Rudolf Edger (Toronto, CA), Asculai; Samuel Simon (Toronto, CA), Hochman; David (Thornhill, CA), Purschke; Don (Toronto, CA), Klein; Ehud Shmuel (Givat Savyon, IL), Harper; David William (Oakville, CA)
Assignee:	Hyal Pharmaceutical Corporation (Mississauga, CA)
Filing Date:	Jun 06, 1995
Application Number:	08/467,994
Claims:	1. A method of manufacturing a pharmaceutical composition from which effective non-toxic dosage amounts may be taken comprising admixing: (1) a therapeutically effective amount of a drug for the topical treatment of a disease or condition of the skin and exposed tissue, said drug selected from the group consisting of a non-steroidal anti-inflammatory drug (NSAID) and a chemotherapeutic drug with; (2) a sufficient amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and its pharmaceutically acceptable salts and combination thereof characterized in that said composition when manufactured comprises 3% by weight of the drug, 21/2% by weight of a form of hyaluronic acid having a molecular weight less than about 750,000 daltons and greater than 150,000 daltons, a solubilizer for solubilizing the drug, and optionally a preservative and the dosage amounts can be taken from the composition in which dosage amounts of component (2) exceeds 5 mg/cm.sup.2 of the skin or exposed tissue to which the dosage amount is to be applied, the composition being in such form that component (2) is immediately available to transport component (1) percutaneously into the epidermis of the skin or exposed tissue to the site of trauma or pathology of the disease or condition to be treated in the skin or exposed tissue, where the dosage amount of the composition accumulates (in the epidermis) for a prolonged period before passage therefrom. 2. A method of treating a disease or condition selected from the group consisting of actinic keratoses, liver spots, squamous cell tumours, malignancies or tumour of the skin, genital warts (condyloma acuminata), cervical cancer, Human Papilloma Virus (HPV), Psoriasis, corns on the feet, and hair loss on the head of pregnant women, said method comprising administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage amount comprising: (1) a therapeutically effective amount of a drug to treat said disease or condition of the skin and exposed tissue and; (2) a form of hyaluronic acid selected from hyaluronic acid and its non-toxic salts and combination thereof, characterized in that said dosage amount of said composition is in a dosage form suitable for topical application to the skin or exposed tissue and in a dosage amount in which component (2) exceeds 5 mg/cm.sup.2 of the skin or exposed tissue to which the dosage amount is to be applied, and is in such form that component (2) is immediately available to transport component (1) percutaneously into the epidermis of the skin or exposed tissue to the site of trauma or pathology of the disease or condition to be treated in the skin or exposed tissue, where the dosage amount of the composition accumulates in the epidermis for a prolonged period before passage therefrom wherein component (1) is between about 1% and about 5% by weight of the composition and component (2) is between about 1% and about 5% weight of the composition and has a molecular weight less than 750,000 daltons and greater than 150,000 daltons. 3. The method of claim 2 wherein component (2) is sodium hyaluronate having between about 1 to about 3% by weight of the composition and component (1) is a non-steroidal anti-inflammatory drug (NSAID) having between about 1 to about 5% by weight of the composition and the balance is selected from the group consisting of excipients suitable for topical application and water. 4. The method of claim 1 wherein component (2) is sodium hyaluronate. 5. The method of claim 1 or 2 wherein component (1) is 3% by weight of diclofenac or didofenac sodium and component (2) is 21/2% by weight of sodium hyaluronate. 6. The method of claim 2, wherein the drug is a non-steroidal anti-inflammatory drug (NSAID). 7. The method of claim 2, 4, or 6 wherein the NSAID is selected from the group consisting of diclofenac, indomethacin, naproxen, (+/-) tromethamine salt of ketorolac, Ibuprofen, piroxicam, propionic acid derivatives, acetylsalicylic acid and flunixin. 8. The method of claim 5 wherein the disease or condition is actinic keratosis lesions.