Details for Patent: 6,153,751
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Title: | Method and compositions for the synthesis of BCH-189 and related compounds |
Abstract: | The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched .beta.-BCH-189 and its analogs. |
Inventor(s): | Liotta; Dennis C. (McDonough, GA), Choi; Woo-Baeg (North Brunswick, NJ) |
Assignee: | Emory University (Atlanta, GA) |
Filing Date: | Jun 22, 1999 |
Application Number: | 09/337,910 |
Claims: | 1. A method of preparing the B-isomer of a 1,3-oxathiolane nucleoside, comprising reacting a compound of the structure: ##STR8## wherein R' is an acyl group and R is an oxygen protecting group, with a protected pyrimidine base in the presence of SnCl.sub.4. |