Details for Patent: 6,143,323

Title:	Tablet composition
Abstract:	A tablet composition containing N-(trans-4-isopropylcydohexanecarbonyl)-D-phenylalanine and low substituted hydroxypropylcellulose is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to inhibit the rise of the blood sugar levels of diabetics after meals.
Inventor(s):	Yabuki; Akira (Kawasaki, JP), Kaida; Masato (Kawasaki, JP), Ando; Takahiko (Kawasaki, JP), Ninomiya; Nobutaka (Kawasaki, JP), Ozaki; Masanao (Kawasaki, JP)
Assignee:	Ajinomoto Co., Inc. (Tokyo, JP)
Filing Date:	May 14, 1999
Application Number:	09/311,060
Claims:	1. A tablet composition containing N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine and 5 to 50% by weight of low substituted hydroxypropylcellulose. 2. A tablet composition containing 5 to 50% by weight of N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine, 5 to 40% by weight of low substituted hydroxypropylcellulose having a hydroxypropyl group content of 5.0 to 16.0% by weight, 10 to 90% by weight of a filler and 0.1 to 5% by weight of hydroxypropyl cellulose having a hydroxypropyl group content of 53.4 to 77.5% by weight. 3. The tablet composition according to claim 1, which further contains a filler. 4. The tablet composition according to claim 3, wherein at least one kind of the filler is lactose. 5. The tablet composition according to claim 1, which further contains hydroxypropyl cellulose. 6. The tablet composition according to claim 5, wherein the hydroxypropyl cellulose contains 53.4 to 77.5% by weight of hydroxypropoxyl group. 7. A tablet composition containing 5 to 50% by weight of N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine, 5 to 40% by weight of low substituted hydroxypropylcellulose and 10 to 90% by weight of a filler. 8. The tablet composition according to claim 7, wherein the filler is lactose. 9. The tablet composition according to claim 7, which further contains hydroxypropyl cellulose. 10. The tablet composition according to claim 9, wherein the hydroxypropyl cellulose contains 53.4 to 77.5% by weight of hydroxypropoxyl group. 11. The tablet composition according to claim 2, wherein the filler is lactose.