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Last Updated: March 28, 2024

Details for Patent: 5,998,367


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Title: Pramlintide pro H-amylin salts and compositions
Abstract:Agonist analogues of amylin and related pharmaceutical compositions, and methods of treatment of diabetes and other insulin-requiring states, as well as methods of treatment of hypoglycemia, are provided.
Inventor(s): Gaeta; Laura S. L. (La Jolla, CA), Jones; Howard (Poway, CA), Albrecht; Elisabeth (San Diego, CA)
Assignee: Amylin Corporation (San Diego, CA)
Filing Date:Jul 14, 1997
Application Number:08/892,549
Claims:1. A pharmaceutically acceptable salt of the peptide ##STR1## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue.

2. A composition comprising a pharmaceutically acceptable salt of the peptide ##STR2## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier.

3. A composition comprising an acetate salt of the peptide ##STR3## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier.

4. A composition comprising a hydrochloride salt of the peptide ##STR4## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier.

5. A composition comprising a trifluoroacetate salt of the peptide ##STR5## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier.

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