Details for Patent: 5,998,367
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Title: | Pramlintide pro H-amylin salts and compositions |
Abstract: | Agonist analogues of amylin and related pharmaceutical compositions, and methods of treatment of diabetes and other insulin-requiring states, as well as methods of treatment of hypoglycemia, are provided. |
Inventor(s): | Gaeta; Laura S. L. (La Jolla, CA), Jones; Howard (Poway, CA), Albrecht; Elisabeth (San Diego, CA) |
Assignee: | Amylin Corporation (San Diego, CA) |
Filing Date: | Jul 14, 1997 |
Application Number: | 08/892,549 |
Claims: | 1. A pharmaceutically acceptable salt of the peptide ##STR1## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue. 2. A composition comprising a pharmaceutically acceptable salt of the peptide ##STR2## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier. 3. A composition comprising an acetate salt of the peptide ##STR3## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier. 4. A composition comprising a hydrochloride salt of the peptide ##STR4## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier. 5. A composition comprising a trifluoroacetate salt of the peptide ##STR5## said peptide having an intramolecular linkage between the cysteine amino acid residues at positions two and seven and tyrosinamide as the thirty-seventh amino acid residue, in a pharmaceutically acceptable carrier. |