Details for Patent: 5,744,500

Title:	Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
Abstract:	The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.
Inventor(s):	Youdim; Moussa B. H. (Remez Tivon, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Yellin; Haim (Ramat-Gan, IL), Veinberg; Alex (Rehovot, IL)
Assignee:	Teva Pharmaceutical Industries, Ltd. (Jerusalem, IL) Technion Research and Development Foundation Ltd. (Haifa, IL)
Filing Date:	May 22, 1995
Application Number:	08/446,439
Claims:	1. A method of treating brain ischemia or stroke in a subject which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat brain ischemia or stroke in the subject. 2. The method of claim 1, wherein the pharmaceutically acceptable salt of R(+)-N-propargyl-1-aminoindan is selected from the group consisting of: the mesylate salt; the ethylsulfonate salt; is the sulfate salt; and the hydrochloride salt. 3. The method of claim 2, wherein the pharmaceutically acceptable salt is the mesylate salt of R(+)-N-propargyl-1-aminoindan. 4. The method of claim 1, wherein the effective amount is from about 0.5 milligrams per kilogram body weight of the subject to about 2.5 milligrams per kilogram body weight of the subject. 5. The method of claim 1, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered intravenously, orally, rectally, transdermally, or parenterally. 6. The method of claim 1, wherein the subject is human and the effective amount is from about 0.01 mg to 50.0 mg per day. 7. The method of claim 6, wherein the effective amount is from 0.1 to 10.0 mg per day. 8. The method of claim 6, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered intravenously. 9. The method of claim 1, wherein the area of the brain ischemia is reduced by about thirty-five percent. 10. A method of treating head trauma injury in a subject which comprises administering to the subject an amount of R (+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat head trauma injury in the subject. 11. The method of claim 10, wherein the pharmaceutically acceptable salt of R(+)-N-propargyl-1-aminoindan is selected from the group consisting of: the mesylate salt; the ethylsulfonate salt; the sulfate salt; and the hydrochloride salt. 12. The method of claim 11, wherein the pharmaceutically acceptable salt is the mesylate salt of R(+)-N-propargyl-1-aminoindan. 13. The method of claim 10, wherein the effective amount is from about 0.5 milligrams per kilogram body weight of the subject to about 2.5 milligrams per kilogram body weight of the subject. 14. The method of claim 10, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered orally, rectally, transdermally, or parenterally. 15. The method of claim 10, wherein the subject is human and the effective amount is from about 0.01 mg to 50.0 mg per day. 16. The method of claim 15, wherein the effective amount is from 0.1 to 10.0 mg per day. 17. The method of claim 15, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered intravenously. 18. A method of treating spinal trauma injury in a subject which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat spinal trauma injury in the subject. 19. The method of claim 18, wherein the pharmaceutically acceptable salt of R(+)-N-propargyl-1-aminoindan is selected from the group consisting of: the mesylate salt; the ethylsulfonate salt; the sulfate salt; and the hydrochloride salt. 20. The method of claim 19, wherein the pharmaceutically acceptable salt is the mesylate salt of R(+)-N-propargyl-1-aminoindan. 21. The method of claim 18, wherein the effective amount is from about 0.5 milligrams per kilogram body weight of the subject to about 2.5 milligrams per kilogram body weight of the subject. 22. The method of claim 18, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered orally, rectally, transdermally, or parenterally. 23. The method of claim 18, wherein the subject is human and the effective amount is from about 0.01 mg to 50.0 mg per day. 24. The method of claim 23, wherein the effective amount is from 0.1 to 10.0 mg per day. 25. The method of claim 23, wherein the R(+)-N-propargyl-1aminoindan or pharmaceutically acceptable salt thereof is administered intravenously. 26. A method of treating neurotrauma in a subject which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat neurotrauma in the subject. 27. The method of claim 26, wherein the pharmaceutically acceptable salt of R(+)-N-propargyl-1-aminoindan is selected from the group consisting of: the mesylate salt; the ethylsulfonate salt; the sulfate salt; and the hydrochloride salt. 28. The method of claim 27, wherein the pharmaceutically acceptable salt is the mesylate salt of R(+)-N-propargyl-1-aminoindan. 29. The method of claim 26, wherein the effective amount is from about 0.5 milligrams per kilogram body weight of the subject to about 2.5 milligrams per kilogram body weight of the subject. 30. The method of claim 26, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered orally, rectally, transdermally, or parenterally. 31. The method of claim 26, wherein the subject is human and the effective amount is from about 0.01 mg to 50.0 mg per day. 32. The method of claim 31, wherein the effective amount is from 0.1 to 10.0 mg per day. 33. The method of claim 31, wherein the R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof is administered intravenously. 34. A method of treating a subject afflicted with a neurodegenerative disease which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat the neurodegenerative disease in the subject. 35. A method of treating a subject afflicted with a neurotoxic injury which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat the neurotoxic injury in the subject. 36. A method of treating a subject afflicted with brain ischemia which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to treat brain ischemia in the subject. 37. A method of preventing nerve damage in a subject which comprises administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof effective to prevent nerve damage in the subject. 38. The method of claim 37, wherein the nerve damage is structural damage of a nerve. 39. The method of claim 38, wherein the nerve is an optic nerve.