Details for Patent: 5,539,116

Title:	Method and compositions for the synthesis of BCH-189 and related compounds
Abstract:	The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched .beta.-BCH-189 and its analogs.
Inventor(s):	Liotta; Dennis C. (Stone Mountain, GA), Choi; Woo-Baeg (Atlanta, GA)
Assignee:	Emory University (Atlanta, GA)
Filing Date:	Feb 10, 1993
Application Number:	08/015,992
Claims:	1. The (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine (BCH-189). 2. The (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine (BCH-189), in substantially pure form. 3. The (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine substantially free of the (+)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine. 4. A composition consisting essentially of the (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine. 5. .beta.-BCH-189 substantially in the form of one optical isomer. 6. A composition consisting essentially of one optical isomer of .beta.-BCH-189. 7. Enantiomerically enriched .beta.-BCH-189.