Details for Patent: 5,024,843

Title:	Oral hypoglycemic glipizide granulation
Abstract:	A dosage form is disclosed comprising the antidiabetic drug glipizide for administering to a patient in need of glipizide therapy.
Inventor(s):	Kuczynski; Anthony L. (Palo Alto, CA), Ayer; Atul D. (Palo Alto, CA), Wong; Patrick S.-L. (Palo Alto, CA)
Assignee:	ALZA Corporation (Palo Alto, CA)
Filing Date:	Sep 05, 1989
Application Number:	07/402,314
Claims:	1. A pharmaceutical granulation comprising granules of 2 mg to 50 mg of substantially aqueous insoluble glipizide, from 100 mg to 320 mg of a polyethylene oxide having a 80,000 to 350,000 molecular weight, and from 5 mg to 50 mg of a hydroxypropylmethylcellulose having a 9,200 to 2,000 molecular weight, which granules are useful for manufacturing an osmotic dosage form for dispensing the glipizide for up to 22 hours when the dosage form is in gastrointestinal tract of a patient. 2. A pharmaceutical granulation comprising granules of 2 mg to 25 mg of substantially aqueous insoluble glipizide, from 40 mg to 70 mg of a polyvinylpyrrolidone having a 30,000 to 70,000 molecular weight, and from 100 to 150 mg of a hydroxypropylcellulose having a 40,000 to 80,000 molecular weight, and wherein the granules are useful for manufacturing an osmotic dosage form for dispensing the glipizide for up to 22 hours when the dosage form is in the gastrointestinal tract of a patient.