Claims for Patent: 5,840,680
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Summary for Patent: 5,840,680
Title: | ASP.sup.B28 insulin crystals |
Abstract: | The present invention relates to insulin crystals comprising ASP.sup.B28 and protamine, and pharmaceutical preparations containing same. The crystals and preparations exhibit rapid onset and prolonged activity when administered in vivo. |
Inventor(s): | Balschmidt; Per (Esper.ae butted.rde, DK) |
Assignee: | Novo Nordisk A/S (Bagsvaerd, DK) |
Application Number: | 08/763,853 |
Patent Claims: |
1. Crystals comprising Asp.sup.B28 human insulin, protamine, and a member selected from the group consisting of phenol, a m-cresol, or a combination thereof.
2. Crystals as defined in claim 1, further comprising zinc. 3. A pharmaceutical formulation comprising crystals as defined in claim 1. 4. A pharmaceutical formulation comprising crystals as defined in claim 2. 5. A pharmaceutical formulation as defined in claim 3, wherein said crystals are suspended in an aqueous medium. 6. A pharmaceutical formulation as defined in claim 4, wherein said crystals are suspended in an aqueous medium. 7. A pharmaceutical formulation as defined in claim 3, further comprising a member selected from the group consisting of an isotonic agent, a buffer, and a combination thereof. 8. A pharmaceutical formulation as defined in claim 4, further comprising a member selected from the group consisting of an isotonic agent, a buffer, and a combination thereof. 9. A pharmaceutical formulation as defined in claim 7, wherein said isotonic agent is selected from the group consisting of sodium chloride and glycerol and said buffer comprises disodium monohydrogen phosphate. 10. A pharmaceutical formulation as defined in claim 8, wherein said isotonic agent is selected from the group consisting of sodium chloride and glycerol and said buffer comprises disodium monohydrogen phosphate. 11. A pharmaceutical formulation as defined in claim 3, further comprising dissolved Asp.sup.B28 human insulin. 12. A pharmaceutical formulation as defied in claim 4, further comprising dissolved Asp.sup.B28 human insulin. 13. A method of treating a patient suffering from diabetes mellitus, said method comprising administering to said patient a pharmaceutical composition as defined in claim 3. 14. A method of treating a patient suffering from diabetes mellitus, said method comprising administering to said patient a pharmaceutical composition as defined in claim 4. |
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