CLINICAL TRIALS PROFILE FOR L-CITRULLINE

Clinical Trials for L-Citrulline

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00280683 ↗	Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma	Completed	National Center for Research Resources (NCRR)	Phase 2	Nitric oxide is an important marker of airway inflammation in asthma. Nitric oxide may have a protective role in patients with moderate to severe asthma. The investigators believe that a natural amino acid, L-arginine, that augments nitric oxide levels can decrease asthma exacerbations and improve the asthma care of moderate to severe asthma patients. This study is a randomized, placebo controlled trial in which subjects will receive either 3 months of L-arginine supplementation or a placebo. The investigators will monitor subjects' symptoms, the number of asthma exacerbations, and lung function. In addition, we will draw blood, obtain induced sputum samples and measure exhaled breath nitric oxide levels at each monthly visit.
NCT00280683 ↗	Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma	Completed	National Institutes of Health (NIH)	Phase 2	Nitric oxide is an important marker of airway inflammation in asthma. Nitric oxide may have a protective role in patients with moderate to severe asthma. The investigators believe that a natural amino acid, L-arginine, that augments nitric oxide levels can decrease asthma exacerbations and improve the asthma care of moderate to severe asthma patients. This study is a randomized, placebo controlled trial in which subjects will receive either 3 months of L-arginine supplementation or a placebo. The investigators will monitor subjects' symptoms, the number of asthma exacerbations, and lung function. In addition, we will draw blood, obtain induced sputum samples and measure exhaled breath nitric oxide levels at each monthly visit.
NCT00280683 ↗	Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma	Completed	University of California, Davis	Phase 2	Nitric oxide is an important marker of airway inflammation in asthma. Nitric oxide may have a protective role in patients with moderate to severe asthma. The investigators believe that a natural amino acid, L-arginine, that augments nitric oxide levels can decrease asthma exacerbations and improve the asthma care of moderate to severe asthma patients. This study is a randomized, placebo controlled trial in which subjects will receive either 3 months of L-arginine supplementation or a placebo. The investigators will monitor subjects' symptoms, the number of asthma exacerbations, and lung function. In addition, we will draw blood, obtain induced sputum samples and measure exhaled breath nitric oxide levels at each monthly visit.

Clinical Trial Conditions for L-Citrulline

Condition Name

Condition Name for
Intervention	Trials
Sickle Cell Disease	5
Asthma	3
Bronchopulmonary Dysplasia	2

Condition MeSH

Condition MeSH for
Intervention	Trials
Anemia, Sickle Cell	6
Hypertension	4
Asthma	3

Clinical Trial Locations for L-Citrulline

Trials by Country

Trials by Country for
Location	Trials
United States	36
Iran, Islamic Republic of	3
Switzerland	3
Tanzania	1
Germany	1

Trials by US State

Trials by US State for
Location	Trials
Mississippi	5
Tennessee	3
Missouri	3
Pennsylvania	2
California	2

Clinical Trial Progress for L-Citrulline

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	5
Phase 2/Phase 3	1

Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase	Trials
Completed	14
Recruiting	7
Unknown status	6

Clinical Trial Sponsors for L-Citrulline

Sponsor Name

Sponsor Name for
Sponsor	Trials
Asklepion Pharmaceuticals, LLC	6
National Institutes of Health (NIH)	4
Vanderbilt University	3

Sponsor Type

Sponsor Type for
Sponsor	Trials
Other	35
Industry	8
NIH	7