Details for Patent: 5,789,395
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Summary for Patent: 5,789,395
| Title: | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| Abstract: | A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions. |
| Inventor(s): | Amin; Ashok R. (Union, NJ), Abramson; Steven B. (Rye, NY), Golub; Lorne M. (Smithtown, NY), Ramamurthy; Nungavaram S. (Smithtown, NY), McNamara; Thomas F. (Port Jefferson, NY), Greenwald; Robert A. (Melville, NY), Trachtman; Howard (New Rochelle, NY) |
| Assignee: | The Research Foundation of State University of New York (Albany, NY) Hospital for Joint Diseases (New York, NY) |
| Application Number: | 08/697,815 |
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Patent Claim Types: see list of patent claims | Use; |
Drugs Protected by US Patent 5,789,395
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International Family Members for US Patent 5,789,395
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Australia | 4080897 | ⤷ Try a Trial | |||
| Australia | 718234 | ⤷ Try a Trial | |||
| Canada | 2264552 | ⤷ Try a Trial | |||
| Canada | 2670296 | ⤷ Try a Trial | |||
| European Patent Office | 0966525 | ⤷ Try a Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
