Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Terminated
National Cancer Institute (NCI)
Phase 1/Phase 2
1997-05-01
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop
growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the
growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor
cells. This phase I/II trial is studying the side effects and best dose of giving
fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how
well it works in treating patients with stage IV colorectal cancer
Safety and Efficacy Study of Interferon Gamma-1b in Hepatitis C Patients With Liver Fibrosis or Cirrhosis
Completed
InterMune
Phase 2
2001-09-01
The purpose of this research study is to test the safety and effectiveness of Interferon
gamma-1b (IFN-g 1b) injected subcutaneously (under the skin) for the treatment of advanced
liver fibrosis and cirrhosis in patients with chronic hepatitis C infections.
IFN-g 1b is not currently approved for the treatment of liver fibrosis.
Post Marketing Surveillance Study of Actimmune in Patients With Severe, Malignant Osteopetrosis
Completed
InterMune
2002-01-01
The purpose of this study is to establish a registry of all children with severe, malignant
osteopetrosis who are treated with Actimmune (IFN-g 1b or Interferon gamma-1b) to monitor the
effects of IFN-g 1b on preventing progression of this disease and to follow the safety of
patients receiving it on a long-term basis. In addition, evaluation of the possible effect of
Actimmune therapy on the humoral response to normal childhood vaccinations in this same
patient population will be examined.Interferon gamma is a substance that the body makes
naturally.
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