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Last Updated: June 2, 2024

Claims for Patent: 11,091,430

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Summary for Patent: 11,091,430

Title:	Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
Abstract:	This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:
Inventor(s):	Anderson Eric, Jiang Xin, Visnick Melean
Assignee:	REATA PHARMACEUTICALS, INC.
Application Number:	US16786429
Patent Claims:	2. The method of claim 1 , wherein the bond joining carbon 9 and carbon 11 of the compound is a double bond.3. The method of claim 1 , wherein the bond joining carbon 9 and carbon 11 of the compound is a single bond.4. The method of claim 1 , wherein said neurodegenerative disease is selected from the group consisting of Parkinson's disease claim 1 , Alzheimer's disease claim 1 , multiple sclerosis (MS) claim 1 , Huntington's disease and amyotrophic lateral sclerosis.5. The method of claim 4 , wherein said neurodegenerative disease is Alzheimer's disease.6. The method of claim 4 , wherein said neurodegenerative disease is MS.7. The method of claim 1 , wherein the compound is administered systemically.8. The method of claim 7 , wherein the compound is administered intravenously claim 7 , intra-arterially claim 7 , intramuscularly claim 7 , intraperitoneally claim 7 , subcutaneously or orally.9. The method of claim 1 , wherein the effective amount is 0.1-1000 mg/kg.10. The method of claim 9 , wherein the effective amount is administered in a single dose per day.11. The method of claim 9 , wherein the effective amount is administered in two or more doses per day.13. The method of claim 12 , wherein the bond joining carbon 9 and carbon 11 of the compound is a double bond.14. The method of claim 12 , wherein the bond joining carbon 9 and carbon 11 of the compound is a single bond.16. The method of claim 15 , wherein the bond joining carbon 9 and carbon 11 of the compound is a double bond.17. The method of claim 15 , wherein the bond joining carbon 9 and carbon 11 of the compound is a single bond.19. The method of claim 18 , wherein the bond joining carbon 9 and carbon 11 of the compound is a double bond.20. The method of claim 18 , wherein the bond joining carbon 9 and carbon 11 of the compound is a single bond.

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